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Novavax Covid-19 Vaccine Candidates May Surpass Major Companies
2019, Novavax It was almost closed after poor management and failed vaccine trials. Today, they are one of the leading companies recognized in the development of coronavirus vaccines.
In September, their coronavirus vaccine candidate NVX-CoV2373 began late-stage clinical trials in the United Kingdom. The United States and Mexico will also enter Phase 3 within a month.
As a small company with less than 200 employees earlier this year, they were funded by the Infectious Disease Control Innovation Coalition and were governmental. Operation warp speed.. At the same time, they are advancing the influenza vaccine NanoFlu and working to get approval from the US Food and Drug Administration.
Development of coronavirus vaccine
Research on the Covid-19 vaccine began shortly after Chinese researchers publicly released the genomic sequence of the virus in early January. R & D President Gregory Glenn and his team worked on the development of a unique version of the coronavirus spike protein. Of the more than 20 versions, the most stable were antibody-inducing proteins that resembled the viral stage immediately prior to fusion with the host cell.
Laboratory tests confirmed that the engineered protein was attached to human cell receptors. The researchers then used an electron microscope to assess how stable the protein structure was. Tests revealed that the engineered spike protein was stable for several weeks between 35.6 ° F and 46.4 ° F. The temperature range should be between -4 ° F and -94 ° F, which is superior to major vaccines that last only a few days after thawing.
To develop NVX-CoV2373, the team used baculovirus, a DNA virus that infects insects, to insert the Covid-19 spike protein into moth cells. The spike protein was then harvested from moth cells and mixed with synthetic particles.Boost immunity Adjuvant The one derived from Kiraya (saponin) has also been added.
Early trials gave better results in both monkey and human tests compared to large companies.Conclusions from Phase 1 and Phase 2 Clinical trial The vaccine candidate appeared safe after 35 days and stated that it “induced an immune response that exceeded levels of Covid-19 convalescent serum.”
Read again: Moderna reveals blueprint for COVID-19 vaccine trial
Is it the best vaccine?
Andrew Ward of Scripps Research and his team have seen in a recent journal publication how good Novavax vaccine candidates are. Science.. Researchers described the structure of the vaccine and “observed new interactions between spike trimers, [the] Formation of higher spike complex. “
Vaccine nanoparticle formation may result in a stronger immune response in the studies described compared to vaccines made solely of soluble trimers. During early monkey and human trials, Ward’s team confirmed how stable the vaccine structure was and how active the antibody response was.
With research on the coronavirus vaccine, the company plans to acquire nearly 300 new employees and expand the Maryland campus for research and development (R & D), manufacturing, and office space. By 2021, we aim to produce the Covid-19 vaccine for 1 billion people alongside our partner manufacturers.
Read again: AstraZeneca / Oxford vaccine shows a good immune response in the elderly
Check out more news and information about vaccine Science Times.
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