This may be the world’s long-awaited breakthrough in the coronavirus – BGR

• Researchers studying the immune response of patients with coronavirus may ultimately be able to explain why they are at risk of developing life-threatening COVID-19 complications.
• COVID Human Genetic Effort details two groundbreaking discoveries on the potentially life-threatening interferon problem in the process of COVID-19.
• Scientists have found that some have autoantibodies to interferon, while others suffer from undiagnosed genetic conditions that affect interferon function.

Whether it’s a new coronavirus or another infection that can cause life-threatening complications, vaccines are only part of the solution.The biggest news of the week is Incredible announcements from Pfizer and BioNTech It says their drug has so far been found to be more than 90% effective against pathogens. The final results of Phase 3 trials can vary and their effectiveness numbers can eventually be low, but it is clearly a good place to start.

As long as thousands of people around the world continue to die from complications, preventing infections and severe COVID-19 cases is not enough. Vaccines will take time to meet demand, and more people will be infected in the meantime. Until most of the world is vaccinated and the risk of infection is significantly reduced, the world still needs effective treatments that can further reduce the risk of death. A pair of studies allow doctors to do just that, a breakthrough corona that can prevent more COVID-19 deaths in the coming months while waiting for vaccines and other effective treatments. It may have led to the discovery of the virus.

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The doctor explained Mid May Coronaviruses do incredibly sneaky things when they infect cells. It blocks the local production of interferon, delays the immune response, and allows the virus to replicate and infect more unchecked cells. Therefore, a large number of teams have begun interferon-based trials, believing that treating COVID-19 with interferon can prevent serious illness.Research from the World Health Organization Display failed The interferon can prevent death. However, with some developments, physicians may be able to fine-tune and further test interferon therapy.

It all started in late September Some studies Described important interferon-related phenomena that may increase the risk of death in COVID-19 patients, including young men. A genetic problem affecting interferon that is not detected until the COVID-19 diagnosis can worsen the prognosis. By looking for hidden interferon imbalances, those studies have shown that doctors can determine which COVID-19 patients are at risk of developing serious complications.

This brings us two larger studies NBC News Just highlightedProvides additional details on interferon problems that can lead to complications.

International team of researchers Presented research at Science This means that 10% of the 987 patients admitted with severe COVID-19 had antibodies that disabled interferon. These are known as autoantibodies and can manifest themselves in autoimmune diseases and medical conditions in which the body attacks itself. Of the patients who had autoantibodies, 94% were male.

This study is from COVID Human Genetic Effort, which includes 200 research centers in 40 countries. Much wider than the September survey.

Interferon autoantibodies were not present in the group of 663 asymptomatic COVID-19 patients. The researchers said that only four of the 1,227 healthy people in the control group had the same autoantibodies. If the data are accurate, doctors treating patients with COVID-19 may start testing for interferon autoantibodies immediately to detect potential severe cases as soon as possible.

People who had autoantibodies to interferon always had them. It is not a by-product of coronavirus infection. It is unclear why other infections such as the flu have not revealed these interferon problems in the past.

“This is one of the most important things we’ve learned about the immune system since the pandemic began,” said Dr. Eric Topol, vice president of Scripps Research. NBC.. Topol was not involved in the study.

This is not the only interferon problem identified by the COVID Human Genetic Effort Group. He also wrote a second study showing that 3.5% of critically ill patients have mutations in genes that control interferon. There are 500 to 600 such genes in the body, and Dr. Qian Zhang says they may identify more mutations. Zhang was the lead author of the second study. This finding can also explain why men of all ages are more affected by interferon problems than women.

“Interferon is like a combination of a fire alarm and a sprinkler system,” explained virologist Angela Rasmusen. NBC.. Rasmussen was not involved in any of the studies. If the virus can suppress interferon activity, people who may suffer from a genetic interferon status may be at increased risk of developing a serious illness.

When the coronavirus arrived, “Your body should have an alarm everywhere,” Zhang explained. “If the alarm doesn’t sound, there can be a lot of viruses everywhere.”

Screening for interferon autoantibodies may become the standard for COVID-19 management, but scientists need more data. NBC Please note that there are more than 100 clinical trials involving interferon and coronavirus. by Clinicaltrials.gov.. New interferon-based therapies may soon emerge from the trial.British doctor Lancet The inhaled version of interferon beta-1a is said to have benefited patients with COVID-19. Randomly assigned people who received the drug were twice as likely to recover completely.This is the promising drug SNG001 from Synairgen first detailed In mid-July..

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