Death from opioid overdose involving other substances commonly found in adolescents

The results of a new study show that opioid overdose deaths involving multiple substances (multi-substances) are more common among adolescents than opioid-only overdose deaths. Data led by researchers at the Greyken Poisoning Center at the Boston Medical Center show that other stimulants, such as cocaine and crystal methamphetamine, are the most commonly involved substances in opioid overdose deaths in young people aged 13 to 25 years. is showing. This study also provides new data. Deaths from opioid overdose involving stimulants in adolescents due to a 351% increase in stimulants between 2010 and 2018. JAMA PediatricsThe study emphasizes that adolescents and young adults need special attention to address the national overdose crisis and cannot focus solely on opioids.

With 8,986 adolescents, according to a survey published in 2018 Young adult He died of opioid poisoning between 1999 and 2016, during which time his mortality rate increased by 268 percent.Data from the Centers for Disease Control and Prevention (CDC) show an increase in opioids Death due to overdose Between 1999 and 2018, other adult substances such as cocaine and methamphetamine are involved.

“Our study provides important insights into what causes opioid-related overdose between adolescents and young adults and helps improve treatment and outcomes in this population,” Boston said. Dr. Scott Hudland, MD, a pediatrician and addiction specialist at the Medical Center, said. Senior author of the study. Hadland is also an assistant professor of pediatrics at Boston University School of Medicine.

Researchers used cross-sectional data from CDC’s extensive online data for epidemiological studies. They include entries classified as deaths with multiple causes and involve opioids such as fentanyl, heroin, and prescription drugs in young people aged 13 to 25 years from January 1999 to December 2018. Death has been identified. Opioid overdose mortality data was collected and further categorized by the presence of other substances such as benzodiazepines, alcohol, antidepressants, cannabis, antipsychotics, barbiturates, cocaine, and other psychostimulants. Data on gender, age, race / ethnicity, and census area were also analyzed.

Mortality from opioid overdose involving opioids alone and multiple substances increased dramatically during the study period to 384% and 760%, respectively. In 2018, there were 4,623 deaths from opioid overdose among adolescents, with synthetic opioids being the most commonly involved (73%). Of these deaths, more than half (2,476) were associated with multiple substances, and deaths from opioid-only overdose were more common than opioid-only deaths.Stimulants, primarily cocaine, contributed 1,541 Death from opioid overdoseAccounted for more than 33% of total overdose in 2018 and 66% of deaths from multi-substance overdose.

“These results emphasize the need to focus on more than opioids during treatment. Young people When Opioid use disorderJamie Lim, MD, a pediatric intern at BMC and Boston Children’s Hospital, said he was the corresponding author of the study. “As providers, we need to be aware of that co-occurrence. Substance Use Disorder Is common and must be dealt with at the same time as treatment Opioid Addiction. ”

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One or more opioids involved in about 80% of OD deaths

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For more information:
Jamie K. Lim et al. Multi-substance involvement in opioid overdose death in adolescents and young adults, 1999-2018. JAMA Pediatr.. Published online on November 23, 2020. DOI: 10.1001 / jamapediatrics.2020.5035

Provided by
Boston Medical Center

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