Health
Cancer cells that “hibernate like a bear” to dodge chemotherapy: research
A new study found that cancer cells present in the body have the ability to hibernate like a “winter bear” to avoid chemotherapy treatment.
This finding also supports the fact that the illness often returns after staying dormant or disappears for several years after treatment.
Preclinical studies of human colorectal cancer cells have shown that they can slow down to a low-maintenance “drug resistance persistence” (DTP) state. This helps explain treatment failure and tumor recurrence.
Catherine O’Brien, a researcher and surgeon at the Princess Margaret Cancer Center in Canada, said:
He added: “There are cases where animals enter a state of reversible and slow division to withstand the harsh environment. Cancer cells seem to have skillfully adopted this same state for the benefit of survival.”
Through their work, researchers have observed that colorectal cancer cells coordinately enter the same hibernation state in the presence of chemotherapeutic agents. The cells stopped growing. In short, there were few nutrients needed to stay alive.
These observations suggest that all cancer cells have the same ability to become DTP, suggesting that these survival strategies may be found in all cancer cells. I will.
For research, researchers conducted experiments in mice. They injected different sets of mice with colorectal cancer cells. The researchers then treated the mice with a standard chemotherapy regimen.
They observed negligible tumor growth in mice treated during the 8 weeks. When treatment stopped, tumor growth began again.
The reproliferated cells remained therapeutically sensitive, and their proliferation stopped and started in the same manner, consistent with the cancer cells entering the DTP state.
This DTP state closely resembles a hibernation-like state called embryonic dormancy, in which mouse embryos fall back as a type of emergency survival mode until environmental conditions become more favorable. Cancer cells apply the same tricks to dodge treatment.
Aaron Shimmer, an oncologist at the Princess Margaret Cancer Center, said: “I didn’t really know that cancer cells are like hibernating bears. This study also targeted these sleeping bears and did not hibernate and unexpectedly returned later. It will teach you how to wake up to come. “
“I think this turns out to be an important cause of drug resistance and explains what we didn’t understand before,” he added.
The research results were published in the journal Cell.
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