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Neonatal antibiotic exposure associated with weight and height loss in boys

Neonatal antibiotic exposure associated with weight and height loss in boys

 


Exposure to antibiotics during the first day of life is thought to affect various physiological aspects of neonatal development. A new study led by Azrieli School of Medicine at Bar-Ilan University found that antibiotic treatment within 14 days of age was associated with weight loss and height loss in boys (not girls) up to 6 years of age. I am.

In contrast, this study showed significantly higher body mass index (BMI) in both boys and girls after neonatal use and antibiotics within 6 years of age.

Survey results published in the journal Nature Communications January 26, 2021 may be the result of changes in the development of the gut flora.

The effects of newborn antibiotic exposure were investigated in a cohort of 12,422 children born between 2008 and 2010 at the Turku University Hospital in Turku, Finland. The baby had no genetic abnormalities or serious chronic disorders that affected growth and did not require long-term antibiotic treatment. Antibiotics were given to 1,151 newborns (9.3%) in this study within 14 days of age.

The authors found that boys exposed to antibiotic treatment showed significantly lower weight compared to unexposed children for the first 6 years. They also showed significantly lower height and BMI between the ages of 2 and 6. This observation was reproduced in a German cohort.

In addition, exposure to antibiotics during the first day of life was found to be associated with impaired gut flora up to age 2. Infants exposed to neonatal antibiotics had significantly lower gut flora abundance than unexposed babies aged 1 month. Interestingly, antibiotic-treated babies reach levels of bacterial abundance in control infants at 6 months of age and are treated with antibiotics at 12 and 24 months of age. Subjects acquired significantly higher levels of bacterial abundance in comparison. For control subjects.

In an additional experiment led by PhD student Atara Uzan, researchers show that sterile male mice fed the intestinal flora of antibiotic-exposed infants also showed growth deficiency. I did. These findings suggest a potential association between neonatal antibiotic exposure and childhood failure to thrive, which may be the result of antibiotic-induced changes in the composition of the gut flora. I am.

Antibiotics are extremely important and life-saving drugs for newborns. Our results suggest that their use may also have undesired long-term consequences that need to be considered. “

Professor Omley Koren, Azrieli Medical School, University of Bar Iran

Professor Omry Koren led the study with Professor Samuli Rautava of the University of Turku and the University of Helsinki.

Follow-up studies aim to investigate other potential adverse outcomes associated with neonatal antibiotic exposure.

The study was also carried out by researchers at the Louzoun Lab at Bar-Ilan University, the Max Rubner Institute in Germany, the Trent University in Italy, and Migal Israel.

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