Health
Dr. Keith Roach: Pernicious anemia comes from a lack of intrinsic factor | For your health
To Dr. Roach • I have been suffering from pernicious anemia for about 8 years and need to inject vitamin B-12 every 3 weeks to stay alive. I have been diabetic for over 10 years, during which time A1C has remained in the range of 6.1 to 6.5. My daily blood glucose measurements are very sensitive to the level of stress in my life, almost overly sensitive. Do you think there is any relationship between the state of pernicious anemia and my A1C? My condition (pernicious anemia) is rare, so there seems to be little research.Impact on various medical problems.. — GP
Answer • Pernicious anemia is not so rare. It is an autoimmune disease in which the body attacks the cells that make acid in the stomach. These cells also make a protein called intrinsic factor that is required for efficient vitamin B-12 absorption. Without B-12, the body is unable to make blood cells effectively, causing anemia, but in severe cases it can damage nerves.Pernicious anemia Now diagnosed by finding antibodies against intrinsic factor, andTheoretically, a single injection lasts much longer, but it is usually treated by injecting B-12 once a month. B-12 is orally absorbed when given in sufficient doses. Oral treatment is just as effective, but a surprising number of patients prefer shots.
Hemoglobin A1C examines the amount of sugar in the hemoglobin molecule. Hemoglobin is the major oxygen-carrying protein in the blood. Conditions that affect red blood cell lifespan affect A1C. However, this is a much larger factor for people with other types of anemia, such as sickle cell disease. In that case, checking many blood sugar levels and looking at the average may be a more effective way to monitor diabetes. Treated pernicious anemia should not affect A1C.
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