Health
Double antibody against SARS-CoV-2 prevents treatment-resistant mutants
“The coronavirus is mutated and will continue to mutate, so we need a treatment that responds to these changes and works effectively on all variants of the virus. This antibody is one step ahead of the virus. It means you can go. ” Qiang Pan-Hammar ström,Professor Department of Bioscience and Nutrition, Karolinska Institute, research co-author and consortium science coordinator.
A single injection of bispecific antibody provided protection against disease in mice. This antibody effectively reduced the viral load in the lungs and reduced the inflammation typical of COVID-19. Antibodies are ideal candidates for human clinical trials and are likely to be used for both prevention and treatment of COVID-19, according to researchers.
Continued need for medicine
“The fact that some people do not respond to the vaccine and it can take years for the whole world to be vaccinated with COVID-19 is a continuous drug that can protect or treat us from the disease. It means there is a need, “says Qiang Pan-Hammarström.
Bispecific antibodies are gaining popularity in the treatment of certain cancers, where some of the antibody may bind to tumor cells and others to immune cells, but researchers say SARS- We first produced a human bispecific antibody against CoV-. 2.2.
The bispecific antibody was developed within the research consortium ATAC, funded by the European Commission last year and coordinated by the Karolinska Institute, in response to the COVID-19 pandemic. Other members include the Institute of Biomedical Sciences (IRB; Bellinzona, Switzerland, Università della Svizzera italiana (USI)), Policlinico San Matteo (Italy), Technische Universitaet Braunschweig (Germany), and the Joint Research Center. .. European Commission. The collaboration between Rockefeller University and the Czech Academy of Sciences has helped prove the effectiveness of bispecificity. See scientific treatises for patents and potential conflicts of interest.
This news article is based on Press release From Biomedical Research Institute.
Publication
“Bispecific IgG neutralizes SARS-CoV-2 mutants and prevents mouse escape.”.. From Gasparo et al. Nature, Online March 25, 2021, doi: 10.1038 / s41586-021-03461-y.
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