Health
Pfizer, a highly effective modeler shot against Indian variants, studies show
Washington: According to a new study conducted by US scientists, the Pfizer and Model Nacovid vaccines should remain highly effective against the two first coronavirus variants identified in India.
Lab-based studies are considered preliminary as they have been conducted by NYU Grossman School of Medicine and NYU Langone Center and have not yet been published in peer-reviewed journals.
“We found that vaccine antibodies are a bit weak against mutants, but not so much that they don’t seem to have a significant impact on the vaccine’s defense capabilities,” said senior author Nathaniel “Ned” Landau. Told to. Monday.
Researchers first took blood from people who were predominant in the United States and were vaccinated with either of the two shots given to more than 150 million Americans.
The lab then exposed these samples to engineered pseudoviral particles containing mutations in the “spike” region of coronavirus specific to either the B.1.617 or B.1.618 variant first discovered in India. I did.
Finally, the mixture was exposed to cells grown in the laboratory to determine the number of cells infected.
The genetically engineered pseudoviral particles contained an enzyme called luciferase, which fireflies use to shed light. When added to the pseudovirus, the number of infected cells can be determined based on light measurements.
Overall, it was found that in the case of B.1.617, the amount of neutralizing antibody was reduced by almost a quarter. – – A Y-shaped protein produced by the immune system to prevent pathogens from entering cells. In the case of B.1.618, the reduction was about three times.
“In other words, some antibodies have stopped working against variants, but there are still many antibodies that work against variants,” Landau said.
“It’s enough to do the work we believe the vaccine is very defensive,” he added.
However, this type of lab study cannot predict what the actual effectiveness will look like. – – It will have to be investigated through other studies.
Coronavirus is known to latch on a specific receptor on human cells called ACE2, which is used to force its invasion.
Landau’s team has shown that Indian variants, like other variant of concern, can bind more strongly to this receptor. This may be related to the higher transmission rate compared to the original strain.
“Our results give us confidence that the current vaccine provides protection against the mutants identified so far,” the team concluded.
However, it does not rule out the possibility of new mutants becoming more resistant to the vaccine. – – It emphasizes the importance of widespread vaccination at the world level.
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