A small study found that the current NHS policy to limit cancer genetic testing could lead to oversight of some people with hereditary genetic changes associated with cancer.
Investigator Cancer Institute The London (ICR) and colleagues said there is a “strong case” for the NHS to increase access to genetic testing and allow more people to receive monitoring, screening, or prophylactic treatment. ..
Private vs NHS screening
The Study in the journal Scientific Reports The 152 people tested at the Private Tumor Genetics Clinic in London between 2014 and 2016 evaluated how many additional genetic variants could lead to intervention and were adopted by the NHS. Compared to eligibility criteria.
Adverse or perhaps adverse genetic mutations associated with a personal or family history of cancer were detected in 15 patients. The detection rate is 10%.
Of these patients, 7 (46.7%) were found by researchers to not meet the NHS test eligibility criteria, accounting for 4.6% of the total number of people reviewed.
They conclude that the current England NHS threshold for genetic testing means that 4.6% of people with a history of cancer in individuals or families may miss genetic testing that could lead to changes in clinical management. I attached it.
However, the study found that 34% of participants had “mutants of unknown importance” and had no clear management policy.
Therefore, expanding the NHS eligibility criteria can increase pressure on the NHS through the need for follow-up checks, but it can also cause unnecessary anxiety in some patients. It puts the patient at risk and minimizes the level of uncertainty. “
Needs larger research
Ros Eeles, a professor of tumor genetics at ICR, said:
She added, “Accurate where the revised NHS threshold for testing should be to maximize the benefits of people at high risk of cancer while minimizing the NHS burden on patients and follow-up. Needs more extensive research to elucidate. “
Professor Kristian Helin, Chief Executive Officer of the ICR, said: Identifying people at the highest risk of cancer and supporting them with strategies for cancer prevention or early detection.
“Unfortunately, access to genetic testing on the NHS is complex and tends to be limited to people with a strong family history. Our new study lacks people who may benefit from genetic testing. We hope that the findings will ultimately help improve. National testing guidelines so that we can help more people at high risk of cancer. “
NHS England said it was unclear whether researchers used the 2014 or 2016 guidelines when concluding what happened at the NHS.
A spokesperson for the NHS England said: National Genomic Test Directory In 2018, this will provide a clear process for reviewing emerging evidence to direct updates that may be needed. “
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Sources
1/ https://Google.com/
2/ https://www.medscape.com/viewarticle/968896
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