Immune cell transplant reverses the effects of aging in mice

One of the many exacerbating effects of human aging is impaired immune system function. This poses many other risks, including vulnerability to infectious diseases. Scientists have discovered a way to reverse this trend, using experiments in mice to not only restore a balanced immune system by targeting abdominal inflammation, but also reduce age-related physical fitness. May have provided a way to deal with.

The research was conducted by an international team led by scientists from the University of Bern, Switzerland. His team started by investigating the function of a special white blood cell called eosinophil that suppresses infection and promotes inflammation. They circulate through the bloodstream, but are also found in abdominal fat, which helps maintain proper immune function in healthy humans.

However, as age increases, the distribution and concentration of eosinophil cells decreases. During that time, the concentration of proinflammatory macrophages in the abdominal fat increases, creating an imbalance that increases with age, causing inflammation and accidentally accelerating the aging process. Scientists have observed this in both mice and humans and wondered if addressing this imbalance could provide a way to change everything.

DBMR, University of Bern, D. Briger

After research, the team found a way that looked promising. Taking eosinophil cells from young, healthy mice and transferring them to aged mice has been shown to reduce inflammation associated with aging.

“Various approaches were able to show that the transfer of eosinophils from young mice to older recipients resolved mild inflammation not only locally but also systemically,” the study author Alexander said. Dr. Eger says. “In these experiments, we observed that transferred eosinophils selectively home to adipose tissue.”

As a result, the immune system function of aged mice was significantly improved. This was demonstrated by the improved vaccination response observed through endurance and grip strength tests and their similar impact on physical performance. Also, aging eosinophil cell imbalances have been observed in humans, so researchers hope these results will lead to new treatments in humans.

“The future direction of our research will be to leverage the knowledge now gained to establish targeted therapeutic approaches to promote and maintain healthy aging in humans,” Eggel said. say.

Research published in journal Natural metabolism..

Source: Bern University

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