Health
Study finds that PET/MRI combination reduces unnecessary prostate biopsies
PET/MRI may improve diagnostic accuracy in prostate cancer patients and help avoid unnecessary biopsies, according to a new study published in the April issue of the journal PET/MRI. nuclear medicine journal. By applying the PRIMARY scoring system to PET/MRI results, researchers found that even if they missed 1 in 8 clinically significant prostate cancer cases, they were able to reduce 80 percent of unnecessary biopsies. I discovered that you can avoid this.
The Prostate Imaging Reporting and Data System (PI-RADS) is a five-point scale used to evaluate suspicion of prostate cancer on MR images. Although PI-RADS category 3 is not indicative of clinically significant prostate cancer, diagnostic challenges remain. Although current guidelines recommend biopsy, fewer than 20% of PI-RADS 3 lesions contain clinically significant prostate cancer.
PI-RADS 3 lesions pose a dilemma for both urologists and patients, as immediate biopsy may be unnecessary. However, monitoring strategies may miss clinically important prostate cancer diagnoses. Therefore, it is clinically important to specifically exclude clinically significant prostate cancer among PI-RADS 3 lesions. ”
Dr. Guo Hongqian, urologist at Nanjing Drumlou Hospital, Affiliated Hospital of Nanjing University Medical College, Nanjing, China
In this study, 56 men with PI-RADS 3 lesions were tested. 68Ga-PSMA PET/MRI. The 5-level PRIMARY system is based on a combination of: 68We reported the prostate using Ga-PSMA pattern, localization, and intensity information. 68Ga-PSMA PET/MRI findings. After imaging, all patients underwent systematic prostate biopsy in combination with targeted biopsy to determine clinically significant prostate cancer.
Of the 56 patients, biopsy detected clinically significant prostate cancer in 8 patients (14.3%). When a PRIMARY score of at least 4 was used to decide on biopsy for men with PI-RADS 3 lesions, 40 of 48 participants (83.3 percent) would be absent compared to 1 in 8 (12.5 percent). Instead, an unnecessary biopsy could have been avoided. Proportion of clinically significant prostate cancer cases.
“By demonstrating added value, 68Ga-PSMA PET/MRI in the classification of PI-RADS 3 lesions, this study provides new insights into the clinical indications of PI-RADS 3 lesions. 68“In the future, PI-RADS 3 patients may be referred for Ga-PSMA PET/MRI,” Guo said. 68Ga-PSMA PET/MRI before prostate biopsy. ”
The study was published online in March 2024.
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Reference magazines:
C, J. other. (2024). Value of 68Ga-PSMA PET/MRI for classifying patients with PI-RADS 3 lesions on multiparametric MRI: a prospective single-center study. nuclear medicine journal. doi.org/10.2967/jnumed.123.266742.
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