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Preliminary data on dexamethasone published for “lifesaving” coronavirus drugs

 


After Oxford University researchers Recently viewed Dexamethasone As a “life-saving” drug treatment COVID-19 (New Coronavirus Infection) (# If there is no character limit, add parentheses when first appearing, Some experts wanted to see additional data.

The preliminary results of the survey were announced on June 16, Release Until Monday at medRxiv vault.

They have not been peer reviewed.

Researchers show that recovery studies show that treatment with dexamethasone (6 mg, which is also a steroid, once a day for up to 10 days) results in 1/100 deaths in oxygenated and ventilated patients. It became clear that 5 decreased-the third.

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Based on these results, the drug prevented one death in about 8 patients on a ventilator, and about 25 patients needed oxygen, the researchers wrote. No benefit was seen in hospitalized COVID-19 patients who did not require oxygen.

“Dexamethasone provides an effective treatment for the most ill patients with COVID-19 and is globally available given its low cost, well-understood safety profile and widespread availability. The researchers wrote.

Known as the recovery trial, this study enrolled 11,320 patients in England, Scotland, Wales, and Northern Ireland. About 2,104 patients were randomly assigned to obtain the drug, and another 4,321 patients received conventional treatment.

The average age of study participants was 66.1 years and more than half of the patients had at least one major comorbidity.

Washington orders face cover on Friday at the start of the state as Coronaville spreads

About 15% of hospitalized COVID-19 patients in the UK participated in this trial.

Without credible evidence from a large randomized clinical trial, researchers pointed out many uncertainties about the efficacy of corticosteroids in COVID-19. However, they write that corticosteroids are widely used in syndromes closely related to COVID-19, such as SARS, MERS, severe influenza, and community-acquired pneumonia.

“The beneficial effects of corticosteroids in severe viral respiratory infections are likely to depend on the right dose in the right patient at the right time,” the study authors write. ing.

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Prior to recovery, many COVID-19 treatment guidelines described corticosteroids as “contraindications” or “not recommended”, but in China, corticosteroids are recommended for severe cases. The study authors state.

The trial was conducted at 176 National Health Service (NHS) hospital organizations in the United Kingdom. The research was funded by the UK Government and private donors such as the Bill and Melinda Gates Foundation.

Chris Ciaccia of Fox News contributed to this report.

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