Health
Tracking mutations in the latest Omicron variants
Even if it changes Omicron Retains status as superior COVID-19 (new coronavirus infection) Mutant. According to the Centers for Disease Control and Prevention (CDC), the BA.5 subvariant currently accounts for 77.9% of cases in the United States.
One study published in International Journal of Molecular ScienceWe sought to gain insight into the effects of Omicron mutation profiles on the interaction of receptors and monoclonal antibodies.
Dr. Kamlendrasin, a professor of veterinary medicine at the University of Missouri, a senior researcher at the Christopher S. Bond Life Science Center, and a research author, said: “Even with vaccines, we continue to find new ways to mutate and avoid existing antibodies. Omicron currently has more than 130 sub-strains, which have been here for quite some time. Is now finally able to detect them and distinguish them in this study. “
As of February 2022, researchers analyzed the available genomic sequences of 8660 for the prevalence of BA.2 mutation profiles. They performed molecular dynamics simulations to determine the structure of spikes / receptors and spike / antibody complexes.
They analyzed the available structures of the spike receptor binding domain (S-RBD) of the original COVID-19 strain, Wuhan-Hu-1 strain, and Omicron strain in combination with a monoclonal antibody and analyzed the mutations at the interface. I understand the function.
Researchers have found significant differences in the number and distribution of mutations between Omicron BA.1 and BA.2. BA.2 maintained important contact with ACE2, which is required for viral entry, but has evolved to further avoid neutralization by monoclonal antibodies. “The combination of these two factors has made BA.2 an amazing variant that can affect current and future vaccination strategies,” the study authors write.
BA.2 has 50 high frequency mutations compared to 48 in BA.1. There were 17 BA.1 mutations that were not present in BA.2 and were replaced by 19 unique mutations and the signature delta mutation G142D. BA.2 had 28 signature spike mutations and BA.1 had 30 mutations. This is because there were two return mutations in the BA.2 RBD, S446G and S496G. Due to this reversion, BA.2 was somewhat similar to Wuhan-Hu-1, but the RBD of BA.2 was more stable than the parent strain.
Researchers have found that BA.2 maintains receptor binding similar to that of the original COVID-19 strain, evades antibody binding even better than BA.1, and may cause high levels with Delta. We conclude that we have evolved with new mutations in order to obtain similar mutations. Infectivity.
Shin said that vaccinated or “naturally” infected people may have produced protective antibodies against some mutants, but these could be nullified as Omicron continues to mutate. He said he had sex. “Various mutations may look like subtle differences, but they are very important,” he said.
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