Increased T1DM risk in children infected with SARS-CoV-2

The incidence of new type 1 diabetes (T1DM) has increased during the COVID-19 pandemic. Children infected with SARS-CoV-2 are more likely to develop diabetes than uninfected children, but previous reports did not distinguish between T1DM and type 2 diabetes (T2DM). . Kendall et al. Studies confirm her increased risk of new-onset T1DM in children (18 years and younger) after SARS-CoV-2 infection.

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Kendall et al. used data from more than 90 million of her patients in 14 countries to identify her 285,628 children diagnosed with SARS-CoV-2 infection between March 2020 and December 2021. We used the TriNetX analytics platform containing anonymized electronic health records. These children were matched for age, sex and self. – Reported diabetic ethnicity, self-reported race and family history in 285,628 children diagnosed with other respiratory infections (known risk factors for T1DM). New diagnoses of T1DM were more frequent in the SARS-CoV-2 cohort than in the respiratory disease cohort at 1, 3, and 6 months post-infection. Her increased risk of type 1 diabetes after SARS-CoV-2 infection persisted when comparing this cohort with children who underwent other healthcare experiences (fractures or healthy visits).

These findings raise concerns about the increased risk of other autoimmune diseases after SARS-CoV-2 and inform the risk-benefit debate regarding prevention and treatment of SARS-CoV-2 infection in the pediatric population. To do.

Original reference: Open JAMA net Fivee2233014 (2022)

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