Skin disease pills also suppress overdose

Researchers at OHSU and others across the country have found a promising link between a skin drug called apremilast and its effectiveness in treating alcohol use disorders. (Getty Images)

Researchers at the Oregon Health & Science University and institutions across the country have identified a pill used to treat common skin conditions as an “incredibly promising” treatment for alcohol use disorders.

The study recently Published in Journal of Clinical Investigation.

Dr. Angela Osburn (Osu)

On average, people taking a drug called apremilast cut their alcohol intake by more than half, from five to two drinks a day.

“I’ve never seen anything like it before,” co-lead author said Dr. Angela Osburnis an associate professor of behavioral neuroscience at the OHSU School of Medicine and a research biologist at the Portland VA Health Care System.

Dr. Colter Grigsby (Osu)

First author is Dr. Colter Grigsbya postdoctoral fellow at the Osburn Institute at OHSU.

Starting in 2015, Ozburn and co-workers searched genetic databases for compounds that likely interfered with the expression of genes known to be associated with heavy alcohol consumption.Apremilast, an FDA-approved anti-inflammatory drug used to treat Psoriasis and Psoriatic Arthritisseemed like a promising candidate.

It was then tested in two unique animal models genetically at risk for binge drinking and in other strains of mice in laboratories around the country. In both cases, apremilast reduced drinking in different models predisposed to mild to severe alcohol use. found to cause an increase in activity.

Researchers at the Scripps Research Institute in La Jolla, California then tested apremilast on people.

The Scripps team conducted a double-blind, placebo-controlled clinical proof-of-concept study with 51 people evaluated over 11 days of treatment.

“Apremilast’s large effect size on reducing alcohol consumption, combined with its good tolerability among participants, suggests that it is an excellent candidate for further evaluation as a new treatment for people with alcohol use disorders. We do,” said the co-lead author. Dr. Barbara MasonPearson Family Professor of Scripps Department of Molecular Medicine.

The clinical study involved people with alcohol use disorders who were not seeking any treatment, and Mason suggested that apremilast may be more effective among people who are motivated to reduce their alcohol consumption. I predict that there will be

“It’s imperative that more clinical trials are conducted with people seeking treatment,” said Osburn. “In this study, we found that apremilast works in mice. It worked in different labs and it worked in people.

Estimated 95,000 in the US die each year from alcohol-related deathsaccording to the National Institute of Alcohol Abuse and Alcoholism.

Three drugs are currently approved alcohol use disorder In the United States, antabuse causes an acute hypersensitivity similar to a hangover when alcohol is consumed. Acamprosate, a drug thought to stabilize chemical signaling in the brain associated with relapse. Naltrexone is a drug that blocks the euphoric effects of both alcohol and opioids.

The work reported here was supported by National Institutes of Health Awards AA016651, AA013519, AA010760, AA07468, AA027692, U01 AA013498, DA013429, P60AA06420, U01AA025476. The U.S. Department of Veterans Affairs awards BX000313, BX004699, and IK2 BX002488. Gift from the John R. Andrews Family. The content is solely the responsibility of the researcher and does not necessarily represent the official views of his NIH or the U.S. Department of Veterans Affairs.

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