Health
Anemia was significantly correlated with COVID-19 mortality
Despite all progress COVID-19 vaccine Even with treatment, some patients still experience severe or fatal disease progression. Therefore, the impetus remains to identify all factors that may increase the risk of COVID-19 morbidity and mortality.
One study presented this week at the 2023 European Conference on Clinical Microbiology and Infectious Diseases (ECCMID), focused on prevalence and prognostic evidence anemia It is still ambiguous in hospitalized COVID-19 patients.
Researchers investigated the association between anemia on admission and the incidence of critical illness and death in COVID-19 patients.
The study authors referenced background information that anemia is a result of acute inflammation and is known to be a predictor of poor clinical outcome in respiratory infections. Overexpression of IL)-1, IL-6, interferon-γ, and tumor necrosis factor (TNF)-α significantly affect iron metabolism and erythropoiesis, leading to anemia.
This retrospective study was conducted in two teaching hospitals in southern Italy. From September 1, 2020 to August 31, 2022, investigators collected data from all adult patients who were hospitalized with her COVID-19. They used Cox’s regression analysis to determine the association between anemia, severe her COVID-19, and in-hospital mortality.
‘Anemia’ was defined as a decrease in hemoglobin (Hb) <13 g/dl in men and <12 g/dl in women. 'Severe COVID-19' was defined as admission to an intensive care unit or sub-intensive care unit, or Quick SOFA (qSOFA) score ≥2 or CURB-65 score ≥3. Propensity scores were used to adjust for associations between anemia and mortality in his two models of potential co-founders.
A total of 1562 patients were included in the analysis. Among his hospitalized COVID-19 patients, the prevalence of anemia was determined to be 45.1%. Patients were also significantly older, reported more comorbidities, and had higher levels of procalcitonin, CRP, ferritin, and IL-6.
The crude mortality rate for patients with anemia was approximately four times higher than for hospitalized COVID-19 patients without anemia. After adjusting the results for 17 potential confounders, the researchers determined that anemia significantly increased her risk of severe COVID-19 and death. These results were confirmed by propensity score analysis.
The researchers concluded that anemia was associated with a more pronounced baseline proinflammatory profile in hospitalized COVID-19 patients and a higher incidence of critical illness and in-hospital mortality. .
This study, “Anemia as a Predictor of Poor Clinical Outcome in Patients Hospitalized with COVID-19: A Large Multicenter Retrospective Cohort Study,” ECCMID 2023.
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