Sleep apnea syndrome may increase long-term risk of new coronavirus infection

Source/disclosure information Disclosure: Mundell has not reported disclosure of related financial information. See this study for relevant financial disclosures of all other authors. Add Topics to Email Alerts Get an email when new articles are posted Enter your email address to receive an email when new articles are posted. . " data-action"subscribe"> Subscribe Your request could not be processed. Please try again later.If this issue persists, please contact us customerservice@slackinc.com. back to helio Important points: After being infected with SARS-CoV-2, adults with obstructive sleep apnea had up to a 75% increased risk of long-term COVID-19. Women with sleep apnea were more likely to develop long-lasting COVID-19 than men. Data show that people with obstructive sleep apnea, especially those with other chronic conditions, are more susceptible to COVID-19 for longer after SARS-CoV-2 infection than people without obstructive sleep apnea. The risk of developing infections was significantly higher. The findings were consistent across multiple research databases and definitions of the novel coronavirus over time, according to the researchers. Hannah Mandel Senior Fellow at New York University Langone Health and his colleagues. Data source: Mandel HL, et al. sleepy. 2023; doi:10.1093/sleep/zsad126. "There are still There's a lot to uncover about the long-running new coronavirusHowever, this study will inform clinical care by identifying patients who should be monitored more closely," Mandel said in a press release. “People with sleep apnea and COVID-19 should seek early treatment, monitor symptoms, and continue vaccinations to reduce their risk of infection.” Research so far We have shown that obstructive sleep apnea (OSA) may increase the risk of severe outcomes of novel coronavirus disease (COVID-19) during the acute phase of infection. as part of the NIH Funded RECOVER InitiativeUsing data from three electronic medical record research networks, the National Patient-Centered Clinical Research Network (PCORnet) and the National Novel Coronavirus Cohort Cohort (N3C), Mandel et al. Evaluate the impact. Both enroll adult patients only, as does the pediatric-focused network PEDSnet. All patients included in the current analysis tested positive for COVID-19 between March 2020 and February 2022. Of the 333,642 adult patients in the PCORnet cohort, 5.1% had OSA and 16.6% probably had long-standing COVID-19 infection. Of the approximately 1.7 million adult patients in the N3C cohort, 3.9% had OSA and 4.9% probably had long-standing novel coronavirus. Finally, of the 106,262 children in the PEDSnet cohort, 1.8% had OSA and 4.6% probably had long-term COVID-19. Across the network, the presumably long-term unadjusted OR of COVID associated with OSA diagnosis ranged from 1.41 to 3.93 in adults and children. Mandel et al. reported that this association remained significant only for adults in comorbidity-adjusted analyses. According to the release, the PCORnet cohort showed a 12% increased risk of long-term COVID-19 infection if previously diagnosed with OSA compared to those without OSA. In the N3C cohort, which included patients with higher levels of other chronic diseases compared with PCORnet patients, OSA diagnosis was associated with a 75% increased long-term COVID-19 risk. Mandel et al. also found that the long-term risk of 2019-nCoV infection in patients with OSA was higher for women than for men in the N3C cohort. Women with OSA had an 89% increased chance of developing long-term COVID-19, while men with OSA had a 59% increase. The study was limited by the lack of data on COVID-19 vaccination status and the low prevalence of OSA compared to previous studies, the researchers said. "Nevertheless, these findings suggest that patients with OSA may be at increased risk for PASC after SARS-CoV-2 and should be monitored for sequelae following acute infection." the researchers concluded. References: perspective back to top Dr. Maewish Sajid This study provides evidence for the need for enhanced long-term COVID-19 monitoring in adults with OSA after COVID-19 infection. This is the first large multi-cohort study to demonstrate that adults with pre-existing OSA are significantly more likely to develop acute sequelae of COVID-19, i.e. long-term infections. Overall, the results of this study are valuable in providing prospective guidance to patients with OSA and clinicians caring for them. Future studies may be informative in determining whether the substantiated findings are affected by OSA treatment and COVID-19 vaccination status. Treatment of OSA has been shown to improve other chronic conditions such as hypertension (improved blood pressure control after CPAP therapy in OSA patients). It would also be beneficial for future research to determine whether long-term novel coronavirus disease probabilities vary by region. OSA severity. The results of this study cannot be generalized across the range of OSA severity at this time. This study highlights the fundamental importance of sleep-disordered breathing screening in primary care settings. Patients with untreated sleep apnea have been found to be at increased risk of developing chronic conditions such as hypertension, diabetes and cardiac arrhythmias. There is now evidence that pre-existing OSA in adults has a high probability of developing long-lasting COVID-19, which may adversely affect patient functioning and independence. Recognizing the above, for patients with pre-existing OSA prior to COVID-19, increased monitoring or more frequent check-ins with their PCP to assess OSA may be warranted. could be beneficial. After being infected with the novel coronavirus disease (COVID-19). Dr. Maewish Sajid Physician in Sleep Medicine and Family Medicine, University of Michigan School of Medicine Clinical Lecturer in Neurology and Family Medicine, University of Michigan School of Medicine Fellow of the American Society of Sleep Medicine Disclosure: Sajid does not report related financial disclosures. 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