Health
Study issues warning about GLP-1 RA use and aspiration risk
Top line:
patients every week glucagonpeptide-1 receptor agonist (GLP-1 RA) has high residual gastric content, which is a major risk factor for aspiration. anesthesiadespite following fasting guidelines before undergoing the elective procedure.
methodology:
- The increasing use of GLP-1 RAs to manage body weight and hyperglycemia has been shown to be safe due to the drug's association with slow gastric emptying, a major risk factor for aspiration under anesthesia. It raises concerns about sexuality.
- In this cross-sectional study, we investigated the association between GLP-1 RA use and the prevalence of increased residual gastric contents using gastric ultrasound.
- All 124 participants (median age 56 years, 60% female) – half of whom received a weekly GLP-1 RA that: Semaglutide, dulaglutideor Tirzepatide — Adhered to the guideline recommended fasting period before undergoing elective procedures under anesthesia.
- The primary outcome focused on identifying increased residual gastric contents, defined by the presence of solids, thick fluid, or clear fluid >1.5 mL/kg on ultrasound.
- In an exploratory analysis, we investigated the association between GLP-1 RA discontinuation duration and increased residual gastric contents.
remove:
- The adjusted prevalence of increased residual gastric contents was 30.5% (95% CI, 9.9% to 51.2%) higher in participants who received GLP-1 RA than in those who did not.
- Although most patients took their last dose of GLP-1 RA within 5 days before the procedure, the increase in residual gastric contents persisted even 7 days after GLP-1 RA discontinuation.
- Additionally, there was no significant association between the type of GLP-1 RA used and the rate of increase in residual gastric contents.
in fact:
“We expect healthcare professionals to encounter these types of drugs more frequently in the perioperative period. Perioperative physicians, including anesthesiologists, surgeons, and primary care physicians We need to be fully informed about the safety implications,” the authors wrote.
sauce:
The study was led by Sudipta Sen, MD, PhD, Department of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School, University of Texas Health Center, Houston, Texas. online March 6, 2024 JAMA surgery.
Limitations:
The primary outcome, residual gastric contents, serves as a surrogate for aspiration risk, and there is no precise volume threshold associated with increased risk. This study did not directly assess aspiration events. The authors also acknowledged that due to the observational nature of the study, there was potential bias due to unmeasured confounders. The small sample size limited our ability to detect differences in risk for each additional day of drug withdrawal before surgery.
Disclosure:
One of the authors reported receiving grant funding from the National Institutes of Health. The authors declared that they had no conflicts of interest.
|
Sources 2/ https://www.medscape.com/viewarticle/study-sounds-alert-about-glp-1-ra-use-and-aspiration-risk-2024a10004jr The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
