Animal studies suggest a link between obesity and periodontal disease | Health

Robert Plate

Monday, December 20, 2021 (HealthDay News)-Although likely to be a rarely considered relationship, new studies in mice suggest that obesity may increase the risk of periodontal disease. I am.

Specifically, chronic inflammation caused by obesity can cause the development of cells called osteoclasts that destroy bone tissue, including the alveolar bone that holds the teeth in place.

“Although there is a clear relationship with the degree of obesity Periodontal disease, The mechanisms that underpin the association between these conditions were not fully understood, “said Dr. Keith Kirkwood, a researcher who is a professor of oral biology at the Buffalo University School of Dentistry.

For a new study, he and his colleagues fed two groups of mice a significantly different diet for 16 weeks. One group was fed a low-fat diet with 10% of the energy from fat and the other group was fed a high-fat diet with 45% of the energy from fat.

Compared to the low-fat group, mice on a high-fat diet showed more obesity, inflammation, and a greater increase in immune cells known as myeloid-derived suppressor (MDSC). They develop into different types of cells in the bone marrow and spleen. Osteoclast..

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