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Lab-made antibodies may be available by the end of summer, says biotechnology CEO

 


It’s a sequel.
Update: Johns Hopkins University has more than 1.3 million cases of coronavirus in the United States, with more than 79,000 deaths in the United States, according to Hopkins. President Donald Trump tweeted that the US would buy $ 3 billion worth. The amount of food from the farm that you provide to the food bank. Due to a new cluster of coronavirus infections, the South Korean capital closed Saturday nightspot of over 2,100 bars, Germany scrambled to stop new outbreaks in slaughterhouses, and Italian authorities Worried that the number was too high, the US economy took part in the cocktail hour during the first weekend cocktail hour in April, losing 20.5 million jobs. This is the steepest and largest decline since the government began tracking data in 1939. CEO of biotechnology company Regeneron said he is optimistic about artificial antibody therapy for coronaviruses. Next month’s clinical trial-said it was too early to see if it could help prevent or treat the infection. “We need to be optimistic about this approach, but we need to get real data. Regeneron CEO Dr. Leonard Schleifer told CNN that in this environment it would replace real science and real data. Indicates nothing, unlike vaccines, which provoke the immune system to generate antibodies, which are produced directly in the lab and provide a temporary immunity into the blood. Our approach takes advantage of what has been known about the immune system for over 100 years, “Schleifer told CNN. The body naturally produces antibodies after being exposed to the virus. “Our approach is, so to speak, to artificially generate these human antibodies and give them those antibodies to prevent them from becoming infected when they are at higher risk, or Treating them, “said Schleifer. According to Regeneron’s Chief Scientific Officer Dr. George Yancopoulos, next month’s trial could potentially be in the hundreds of thousands of doses by the end of summer. “Vaccines can bring permanent immunity to far more people,” he said, “he is the reason why all these efforts are needed,” he said. The coronavirus model often quoted by the White House has come to predict more deaths in the United States. This is a shift that top researchers have tied to “an explosive increase in mobility in many states”. The University of Washington’s Health Metrics and Assessment Institute (IHME) model predicts 137,000 deaths in the United States by August, from a previous forecast of about 134,000. “I’m building a model for CBS today,” said Dr. Christopher Murray, director of IHME. “In many states, which are expected to lead to more cases and deaths within the next 10 days, There is an explosive increase in mobility. ” While the resurgence of the US epidemic or “return to exponential growth” has not yet been predicted, mobile phone data still indicate more Americans are moving. This suggests that more infections will occur. “That’s the main driver,” says Murray. “In some states, you’ll see a 20% point gain in just 10 days of mobility, which translates into more people and more infections.” IHME also said More people than expected in the case and in certain places were killed. “But it’s mainly mobility that is driving that number,” he says, partly as a result of social distance mitigation measures. “ While it is expected that mitigation of social distances will increase, mobility will continue to increase, but where the social distance obligations continue to take place and when the death toll approaches 79,000, Ministry of Health officials Warned Mother’s Day gatherings and health officials across the country warned Americans against refusing to celebrate Mother’s Day in a large crowd this year, urging them to maintain social distance. Now, after tracing the cluster of cases back to a birthday party, authorities warned, and in the state of Louisiana, the Department of Health recommended a festive alternative, such as a virtual brunch. To keep the distance of 6 feet, “said the Louisiana Department of Public Health. Despite the nationwide increase in deaths, Tate begins the first phase of resuming the economy. And last week another alarming news came: New York state officials said the inflammatory disease (killing two children and teens) observed in dozens of young people was linked to the virus. I have believed that they could be, but demanded that the residents and business owners who initiated mitigation measures throughout the US in a protest wipe out the orders at home. And more protests are being formed across the country by residents who refuse to wear face coverings, as the state is working to find ways to new normals. Public health experts warn that the United States is not ready to begin a resumption-especially due to lack of adequate testing and contact tracking efforts-premature lifting of the measures It could mean twice as many people died as predicted. However, the effects of the mitigation measures will not be apparent for some time, “he said. Symptoms, “the coronavirus projection model is quoted from the CDC, data scientist Youyang Gu is a public health expert representing CNN.Dr. I’ll be back on the same boat as before, “he said, which could see a rebound of the virus. The virus-infected health official is one of a handful of top government and health officials who have announced contact with infected people in the White House. Fochie contacted CNN to announce a “low-risk” call and to launch “corrected quarantine” White House staff tested positive for virus. Fouch wasn’t close to him, but said he would work from home for the next two weeks, put on a mask, and add that he might go to his office where he was alone. Robert Redfield, director of the Centers for Disease Control and Prevention, will self-quarantine for two weeks after being exposed to a White House virus-positive person confirmed by a CDC spokesperson to CNN. An FDA spokeswoman confirmed to CNN on Friday that FDA spokesman contacted him for being positive for the virus, after which Food and Drug Administration member Stephen Hahn will also be in quarantine. Or Redfield has been published. But Vice President Mike Pence’s reporter Katie Miller gave a positive test Friday. She is known to frequently attend White House Coronavirus Headquarters meetings. Diseases found in children may be related to viruses In New York, state authorities have partnered with federal authorities to provide other states with information after the death of three young people Link to the virus It has been. State officials said Saturday that an inflammatory disease observed in dozens of New York children killed a teenager and two children under the age of eight, which could be related to the virus. Said there is. Not affected by COVID-19. ” “We are no longer convinced that it is the case,” the researchers don’t yet know if the coronavirus caused the syndrome. According to Cuomo, this is under investigation. “We’re still learning a lot about the virus,” state officials said previously that dozens of children in the state may have been linked to the syndrome by coronaviruses. Is there. The children had fever and symptoms similar to toxic shock syndrome and Kawasaki disease. Kawasaki disease causes inflammation of the walls of blood vessels, including those that supply the heart with blood, and can rarely lead to a fatal restriction of blood flow. Many children were virus-positive or carried the antibody, Cuomo said. However, they did not necessarily show typical symptoms of coronavirus disease, such as dyspnea.
It’s a sequel.

latest:

  • According to the report, there were more than 1.3 million cases of coronavirus in the United States, Johns Hopkins University Tally..
  • According to Hopkins, the death toll in the United States exceeds 79,000.
  • President Donald Trump tweeted that the United States will buy $ 3 billion worth of food from farms and provide it to food banks.
  • The Korean capital closed Saturday night with more than 2,100 bar nightspots due to a new cluster of coronavirus infections, Germany scrambled to stop new outbreaks in slaughterhouses, and Italian authorities said I was worried that people would be too friendly during the first weekend cocktail hour. The restrictions have been relaxed.
  • The Bureau of Labor Statistics announced on Friday that the US economy lost 20.5 million jobs in April-the sharpest and largest decline since the government began tracking data in 1939.

Biotechnology company Regeneron’s CEO said he was optimistic about artificial antibody treatments for coronaviruses that could enter clinical trials next month, but it’s time to know if it can help prevent or treat infections. He said it was too early.

“We need to be optimistic about this approach, but we need to get the actual data. In this environment, there is no substitute for real science or real data,” said Leonard, CEO of Regeneron. Dr Schleifer told CNN.

Unlike vaccines, which induce the immune system to generate antibodies, laboratory-produced antibodies are directly injected into the blood to provide temporary immunity.

“Our approach takes advantage of what has been known about the immune system for over 100 years,” Schleifer told CNN.

He said the body naturally produces antibodies after being exposed to the virus.

“Our approach is, so to speak, artificially producing these human antibodies and giving them those antibodies to prevent them from becoming infected when they are at higher risk, or to To treat, “said Schleifer.

According to Dr. George Yancopoulos, Chief Science Officer of Regeneron, the company wants to participate in a clinical trial next month, which could allow hundreds of thousands of doses by the end of summer.

Jancopros explained that treatments until the vaccine became available were “significant temporary gaps,” they said they were complementary, and said at ABC.

“Vaccines can bring a lasting immunity to far more people,” he said. “That’s why we need all these efforts.”

The model predicts more US deaths as states identify “explosive” increases in mobility

The major coronavirus models often cited by the White House have come to predict more deaths in the United States.

The University of Washington’s Health Metrics and Assessment Institute (IHME) model predicts 137,000 deaths in the United States by August, from a previous forecast of about 134,000.

Dr. Christopher Murray, director of IHME, discussed the CBS model today.

“We see explosive growth in mobility in many states, and we expect to see more cases and deaths in the next 10 days,” Murray said.

Murray said in a press release that the model had not yet predicted a resurgence or “return to exponential growth” in the U.S. epidemic, but mobile phone data will continue to drive more Americans. It indicates that

“In short, it’s the increase in mobility that drives change, and that’s a major driver,” Murray says. “In some states, you’ll see a 20 percentage point gain in just 10 days of travel, which will result in more people coming in and more infections.”

IHME is also experiencing more cases and deaths than expected in certain locations. “But that’s largely driven by mobility,” Murray said, in part, as a result of social distance mitigation.

“While there is expected to be a relaxation of social distances, there is an increase in mobility, but it certainly correlates with where the social distance obligations are removed so that the mobility bump looks bigger. It has something to do, “he said.

Health officials warn of Mother’s Day gatherings as death toll approaches 79,000

Health officials across the country have warned Americans to refrain from celebrating Mother’s Day in this year’s large crowd, and continued social distance is still the key to preventing cases of coronaviruses Insists.

In Pasadena, California, authorities warned after tracking the cluster of events back to a birthday party, and in Louisiana, the Health Department recommended festive alternatives such as virtual brunch.

“Don’t give in to the temptation to hug your mom and maintain a 6 foot gap.” Louisiana Department of Public Health The above.

Notifications come when most states have begun the first phase of economic resumption, despite an increase in death toll nationwide.

And last week another disturbing news came. New York state officials believe that the inflammatory disease (which killed two and teenagers) observed in dozens of adolescents may be related to the virus.

However, the governor began to ease measures throughout the United States in protest from residents and business owners demanding that home orders be wiped out. And more protests are being formed across the country by residents who refuse to wear face coverings, as the state is working to find ways to new normals.

Public health experts warn that the United States is not ready to begin a resumption-especially due to lack of adequate testing and contact tracking efforts-premature lifting of the measures It could mean twice as many people died as predicted. However, the effect of loosening measures will be unclear for a while.

“It takes at least 2-3 weeks for the number of infections to increase, because it takes time for individuals to infect others and develop symptoms,” said Youyang Gu, a data scientist quoting a coronavirus prediction model. CDC told CNN.

Dr. Anthony Fauci, the country’s leading public health expert, said that if the measures were taken too early, the US could see a backlash of the virus returning in the same boat as it did weeks ago. “

The best health authorities exposed to the virus

Forch is one of a handful of government and health officials who have announced contact with infected people at the White House.

Fauci told CNN that it would initiate a “corrected quarantine” after “low-risk” contact with White House staff who tested positive for the virus. Fouch wasn’t near the person, but he said he would spend the next two weeks working at home wearing a mask, adding that he might go to his office alone.

Dr. Robert Redfield, director of the Centers for Disease Control and Prevention, will self-quarantine for two weeks after exposing the White House virus positives identified by a CDC spokeswoman to CNN.

A FDA spokeswoman confirmed with CNN on Friday that Dr. Stephen Hahn, director of the US Food and Drug Administration, will also go into quarantine after contacting individuals who have been tested positive for the virus.

Authorities did not identify who Hahn or Redfield was exposed to. But Vice President Mike Pence’s reporter Katie Miller gave a positive test Friday. She is known for her frequent participation in White House Coronavirus Headquarters meetings.

Diseases found in children may be related to viruses

In New York, state authorities have partnered with federal authorities to provide other states with post-mortem information about three young people who may be related to the virus.

State officials announced Saturday that two children under their teens and under eight died of an inflammatory disease observed in dozens of New York children.

They said the disease could be related to the virus.

“We were working under the impression that young people were not affected by COVID-19,” Governor Andrew Cuomo said. “We are not so convinced that it is a fact anymore.”

Researchers still do not know if the coronavirus caused the syndrome. But this is under investigation, Cuomo said.

“There’s still a lot to learn about this virus,” he said.

State officials had previously warned that dozens of children in the state were hospitalized with doctors in a condition called “pediatric multisystemic inflammatory syndrome” and could be related to coronaviruses. ..

The children had fever and symptoms similar to toxic shock syndrome and Kawasaki disease, the state said. Kawasaki disease causes inflammation of the walls of blood vessels, including those that supply the heart with blood, and, in rare cases, can lead to fatal restriction of blood flow.

According to Cuomo, many children were virus-positive or carried antibodies, but did not necessarily show typical symptoms of coronavirus disease, such as dyspnea.

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