Health
Long-term use of blood pressure medications can contribute to kidney damage
A new kidney study at the University of Virginia School of Medicine raises concerns that long-term use of commonly prescribed drugs to treat high blood pressure and heart failure may contribute to kidney damage.
Researchers say patients should continue to take medications, including well-known and widely used ACE inhibitors. But scientists are urging research to better understand the long-term effects of drugs.
Our studies show that renin-producing cells are the cause of damage. We now understand how these cells, which are very important to protect us from lowering blood pressure and maintain our well-being, make such changes and cause kidney damage. Focuses on that. What is needed is to identify substances that lead to the growth of blood vessels that these cells cannot control. “
Maria Luisa Sequeira Lopez Doctor of Medicine, UVA Pediatrics and Pediatric Health Research Center
Causes of kidney damage
Chronic hypertension affects 1 billion people worldwide. UVA researchers wanted to better understand why severe conditions often involve thickening of the arteries and small blood vessels of the kidneys, leading to organ damage.
They discovered that special kidney cells, called renin cells, play an important role. These cells usually produce renin, an important hormone that helps the body regulate blood pressure. However, harmful changes in renin cells can cause the cells to invade the walls of blood vessels in the kidney. The renin cells then cause the accumulation of another cell type, smooth muscle cells, which causes the blood vessels to thicken and harden. Result: Blood cannot flow through the kidneys.
In addition, researchers have found that long-term use of drugs that inhibit the renin-angiotensin system, such as ACE inhibitors, or Angiotensin receptor blocker, Has the same effect. These drugs are widely used for many purposes, including treating hypertension, congestive heart failure, heart attack, and preventing major heart problems. However, scientists have found that long-term use of the drug was associated with hardened kidney vessels in both laboratory mice and humans.
Researchers have pointed out that the drug can save the lives of patients, so they emphasize the importance of continuing to take the drug. However, they say additional research is needed to better understand the long-term effects of the drug on the kidneys.
Ariel Gomez, MD, Ph.D., Center for Pediatrics and Pediatric Health Research, UVA, said: “While hypertension is being treated with current drugs currently available, it is essential to find out which molecules these cells make so that they can be counteracted to prevent damage.”
Published survey results
Researchers published their findings in scientific journals JCI Insight. The article was chosen as a cover story. The research team consisted of Hirofumi Watanabe, Alexander G. Martini, Evan A. Brown, Schwinn Liang, Silvia Medrano, Shin Goto, Ichiei Narita, Royce J. Allend, Seceira Lopez, and Gomez. ..
This study was supported by the National Institutes of Health and funded P50 DK 096373, R01 DK 116718, R01 DK 116196, R01 DK 096373, and R01 HL 148044. Japan Society for the Promotion of Science Overseas Researchers Association.
Source:
Journal reference:
Hideki Watanabe, et al. (2021) Inhibition of the renin-angiotensin system causes concentric hypertrophy of the renal arterioles of mice and humans. JCI Insight. doi.org/10.1172/jci.insight.154337..
..
|
Sources 2/ https://www.news-medical.net/news/20220112/Long-term-use-of-blood-pressure-medication-could-be-contributing-to-kidney-damage.aspx The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
