Various levels of lipoprotein cholesterol related to dementia

The low -density lipoprotein (LDL) cholesterol and total cholesterol fluctuation level of the elderly living in the community may be a biomarker with dementia and a decrease in cognitive function. Neurology。¹

Elderly people often suffer from dementia² And if it is caught early, the general cognitive decline, along with the ability to slower the progress. The relationship between the lipid level and the decrease in the nerve cognitive function has been defined and has not been studied. The purpose of this study is to use other large -scale randomization test data to evaluate the relationship between variability in lipid measurement, reduced cognitive function of the elderly, and risk of dementia. 。

This study contained data from aspreyin in the ASPREE-to-the-trial phase of the elderly (ASPREE) and the after-trial observation stage. In this survey, both Australia and the United States recruited people over the age of 70. The US ethnic minority may be over 65 years old. All participants had no independence, had dementia, significant dementia, or had a physical disorder that diagnosed the events of previous cardiovascular diseases. ASPREE ended in June 2017 with the data -off day of 2021, but the observation after the trial is still ongoing.

If the level of total cholesterol and lipoprotein changes year by year, the risk of dementia is high | Image credit: Comzeal -stock.adobe.com

After fasting, we collected blood samples from each participant. All blood samples were collected at local clinics or pathological centers. LDL cholesterol was calculated by all patients based on blood samples. All participants included in the analysis were collected four blood samples. One is the bass line, a collection of the next three years. Participants who started or discontinued lipid deterioration treatment were excluded from research, as the purpose was to evaluate fluctuations other than the change in treatment.

The main results were LDL cholesterol, high -density lipoprotein (HDL) cholesterol, and triglyceride, so it was a change in total cholesterol each year. The main endpoints were all causative dementia. The changes in cognitive impairment without dementia and domain -specific cognitive -specific cognitive has been an endpoint of research. These endpoints were measured using global cognitive functions, episode memory, language, execution function, and mental motor speed tests.

The study contained 9846 participants, of which 54.9 % were women and the median age was 73.9 (71.7-77.3). Total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride's absolute changes were 2.36, 2.07, 0.81, and 1.46 mmol/L in a maximum of about four minutes. Absolute changes were 1.02, 0.92, 0.35, and 0.57 mmol/L, respectively.

A total of 5 % of the participants developed dementia during the tracking period of 5.8 (4.5-7.1). The highness of dementia was found in about the lowest quarter (11.3 to 7.1 cases per 1000 years a year) in a highly variable total cholesterol variable. The risk of dementia was the second lowest, the second largest, 37 %, 44 %, and 60 % in the highest quarter. The risk of dementia increased by 13 % and 12 %, and the variability of total cholesterol and LDL cholesterol was discovered by 1 SD.

A total of 25 % of the participants experienced a deterioration of cognitive function after the follow-up of 5.4 (4.1-6.5). Patients with a maximum four-minute patient of total cholesterol and LDL cholesterol had the highest risk of decreasing cognitive function (total cholesterol: 1.23; 95 % CI, 1.08-1.41 and LDL cholesterol: HR, 1.27; 95 % CI, 1.11 -1.46) Compared to the lowest quarter number. In patients, which have a high number of variability of total cholesterol and LDL cholesterol, a rapid decline in global cognition, mental momentum, and episode memory has been found.

This study had several restrictions. Changes in lipid lipid doses or non -compliance may have explained the fluctuations in the total cholesterol and LDL cholesterol level. The data of this study is due to clinical trials that are more likely to register healthy participants and to limit the possibility of generalization. This study did not explain the meal pattern. Reverse causal relationship is possible.

Researchers concluded that the risk of dementia, decrease in cognitive function, and cognitive impairment was high, and said that the variability of the total cholesterol and LDL cholesterol in the elderly. In future research, it is necessary to focus on whether a lipid variable person is qualified as a high risk group.

reference

1. Related to Zhou Z, Moran C, Murray AM, the deterioration of cognitive function of the elderly living in other communities and the risk of dementia and the annual lipid fluctuation. Neurology。 2025; 104 (4): E210247. Doi: 10.1212/WNL.000000210247
2. Fact sheet: Tendency of dementia. Population reference bureau. Access January 30, 2025