More years with type 2 diabetes, higher risk of dementia

Thursday, April 29, 2021 (HealthDay News)-Young people are about to grow Type 2 diabetes, High risk dementia Later, new research suggests.

Many studies have pointed out an association between diabetes and a higher risk of dementia.Experts say it’s because diabetes can be harmful brain In several ways.

Now, new findings suggest that young people with diabetes may be at particular risk in the future.

Studies show that people who were recently diagnosed with type 2 diabetes at the age of 70 were not at higher risk of dementia than people without diabetes. The situation for people diagnosed more than 10 years ago was different. They had twice the risk of dementia compared to people of the same age who did not have diabetes.

It may simply be because they have lived with diabetes for years.

“A younger age of onset of diabetes means a longer duration, which allows all side effects of diabetes to develop over a longer period of time,” said lead researcher Arcana Singh Manu. .. She is a research professor at the University of Paris and the French National Institute of Health Sciences.

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Type 2 diabetes occurs when the body becomes insensitive Insulin, Hormones to regulate Blood sugar.. It causes chronic hyperglycemia and can damage both large and small blood vessels throughout the body over time.

These effects, which can impair blood flow to the brain, are one of the reasons diabetes is associated with dementia, Shinmanu said.

She also pointed out other potential pathways: insulin plays a role in brain function and diabetes may prevent it from doing its job. Diabetes treatment, on the other hand, can cause frequent episodes of hypoglycemia, which can also harm the brain over time, Shinmanu said.

Survey results were released on April 27 Journal of American Medical Association, Has a wide range of public health effects.

According to the American Diabetes Association, more than 34 million people in the United States alone have diabetes, the majority of whom have type 2 diabetes.

Once upon a time, type 2 diabetes was a disease of the elderly. However, as the prevalence of obesity, a major risk factor for type 2 diabetes, is increasing, the disease is increasingly being diagnosed in adolescents.

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“The prevalence of diabetes continues to increase and the age of onset is getting younger,” said Shin Manu.

This means that more people will live longer with diabetes and become vulnerable to diabetic complications. According to Shin Manu, it is already known that younger people with diabetes are at higher risk of heart disease, stroke and premature death.

She said the study would add dementia to the list.

The survey first included more than 10,000 adults in the United Kingdom between the ages of 35 and 55 in the 1980s. Over the next 30 years, 1,710 people developed type 2 diabetes and 639 were diagnosed with dementia.

At age 70, people who developed diabetes within the last five years were not at higher risk of dementia than people without diabetes.

However, those diagnosed more than 10 years ago have shown that their risk of dementia is doubled. Their actual incidence of brain disease was about 9 per 1,000 adults without diabetes, compared to 18 per 1,000 annually.

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“What we do in young and middle age will change the way we grow older,” she said.

For more information

More about the American Diabetes Association Management of type 2 diabetes.

Source: Archana Singh-Manoux, PhD, University of Paris, INSERM, Professor of Research in Paris. Medha Munshi, MD, Director of the Joslin Diabetes Center’s Senile Diabetes Program, and Associate Professor of Harvard Medical School in Boston. Journal of American Medical Association, April 27, 2021