Health
60% Objective Response Rate Demonstrated in Advanced Melanoma Treatment Studies — Precision Vaccination
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Based in Norway Ultimovacs ASA We announced the universal cancer vaccine today, UV1Showed an objective response rate (ORR) of 60% in metastatic melanoma in combination with the checkpoint inhibitor pembrolizumab.
All patients in this Phase 1 study have been observed for at least 18 months with a median observation period of 21 months.
60% ORR of 30% CR (6 complete response (CR); 6 partial response (PR) from a cohort of 20 patients) was the response rate of pembrolizumab alone in advanced melanoma (33-37% ORR and It clearly exceeds 5-12). % CR).
The median progression-free survival for UV1 / pembrolizumab combination therapy in this study was 18.9 months, compared with pembrolizumab alone for advanced melanoma of 5.5 to 11.6 months. Overall survival is 80%, and median overall survival has not yet been reached after 21 months of follow-up.
“These extremely powerful and exciting data further strengthen the foundation of UV1’s broader Phase II clinical program,” Ultimovacs Chief Medical Officer Jens Bjørheim commented in a press statement.
“Our development strategy shows that UV1 can significantly improve therapeutic efficacy in a wide range of indications and combinations, as it is safe and tolerated in combination with pembrolizumab and exhibits this level of beneficial clinical response. Is emphasized. “
According to the company, ” UV1 Patients with advanced malignant melanoma often lack the associated T cells to benefit permanently from pembrolizumab alone. UV1 enlarges T cells, which can increase the breadth and diversity of the immune response to all parts of the tumor.
The data is from the Ultimovacs open-label Phase I trial (NCT03538314) and will be presented as a poster presentation that will take place virtually from Friday, June 4, 2021 to Tuesday, June 8, 2021. The data show that the combination of UV1 / pembrolizumab is well tolerated and adverse events are primarily limited to low-grade effects such as injection site reactions.
Ultimovacs Founded in 2011, its proprietary technology is based on clinical research conducted at the University of Oslo Hospital. The company is a limited liability company listed on the Oslo Stock Exchange in Norway.
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